GENERAL PATHOLOGY

General Module

Course Sheet

Course code:

TP11A6B

Academic Year of enrolment:

2018

Year of supply:

2018/2019

Type of Course:

Basic

Degree:

Course of 1st Cycle Degree in ENVIRONMENT AND WORKPLACE PREVENTION TECHNIQUES

Disciplinary Sector:

General Pathology

Is part of:

PHYSIOPATOLOGY AND MICROBIOLOGY

Location:

CHIETI

Credits:

Programme Year:

Professor and Collaborators:

REALE Marcella

Cycle:

Second semester

Obligatory attendance:

Yes

Hours of classroom activity:

Individual study hours:

Prerequisites:

knowledge of cellular and molecular biology, histology and biochemistry, acquired in the curricular courses and the.prerequisites required by the core curriculum of CdS

Objectives

The main purpose of the course is to give students the essential knowledge of the fundamental pathological processes that are the basis of diseases and immunology, preparatory to the study of the other disciplines foreseen by the core curriculum.
In particular, the course aims to provide the student with the basic elements of cellular pathology and pathophysiology for the elemental understanding of the inflammatory response, the tissue repair processes, the main immunopathologies and neoplastic diseases.
At the end of the course, the student will be able to know and understand the main factors present in the environments that affect human health, the characteristics of cellular and tissue response to chemical and physical agents. The students will have learned how a cellular damage is organized in professional illness. And they will have learned the main inflammatory and degenerative pathological processes.
Skills:
The student will also be able to apply the acquired knowledge to the prevention activity in living and working environments. Moreover, by the moments of discussion and in-depth analysis and by the consultation of texts carried out during the course, the student will be able to collect, read and interpret data useful to formulate an independent judgment on the main topics pertinent to the discipline.

Contents

Etiology, Pathogenesis, homeostasis.
Cell adaptations and death.
Immunology and immunopathology
Inflammation
Oncology

Extended Syllabus

General concept of health, disease and homeostasis. Intrinsic and extrinsic pathogenic factors. The environment as a cause of illness: pathology from physical, chemical and biological agents. Radiation disorders, immediate and late effects; electric currents, high and low temperatures: heat stroke, burns; freezing. Trauma disorders.
-Cellular adaptation: hypertrophy, hyperplasia, atrophy, aplasia, hypoplasia, metaplasia, dysplasia, anaplasia.Cell death. Apoptosis. Characteristics and phases of necrosis. Types of coagulative necrosis, colliquative, caseous, fibrinoid).
-Inflammation. Angioflogosis: phases and evolution (vascular changes, cellular events, chemical mediators). Exudate. Histoflogosis: phases and evolution. Granulomas. Systemic manifestations of inflammation. Regeneration, repair (granulation tissue, scar tissue) and wound healing.
-Immunology and Immunopathology. Non-specific and specific immunity. Mechanisms of the humoral and cell-mediated response (antibodies, antigens of the major histocompatibility complex, complement). Hypersensitivity reactions of type I, II, III and IV and related diseases.
-Oncology. Characteristics of benign and malignant neoplasms. Classification criteria for neoplasms. Definition of oncogenes and tumor suppressor genes. Tumor growth biology: cell differentiation, tumor progression, invasiveness and metastasis.
Environmental carcinogenesis. Starting and promoting agents. Phases of carcinogenesis.

Recommended Bibliography

Pontieri G.M.: Patologia generale per i C.d.L. in professioni sanitarie. Piccin

Teaching Methods

Knowledge will be acquired by single-issue lessons on all the topics of the course, with projection and discussion of illustrative slides. During the lessons there will be moments of discussion on specific topics to facilitate the understanding of the topics and the development of links between the topics. The learning of some issues can also be implemented by consulting texts provided by the teacher

Evaluation methods

Verification of learning:

The verification of learning will be done by oral examination. It consists of an interview with the teacher. The interview is aimed at evaluating the student in the knowledge of the main concepts represented in the course objectives of the course; in the ability to use appropriate terminology; in the ability of critical synthesis of the topics dealt with also through the deepening in the recommended text

Contacts/More Information

The frequency at the lessons is mandatory and the final exam can be supported upon the acquisition of the frequency signature and in compliance with the prerequisites. As reported in the study plan.
The teacher is available for clarification to the students, in the time of receipt, by appointment.
From Monday to Friday dal lunedì al 10.00- 12.00
N.P.D., edificio C, III livello, tel. al 0871 3554029 mail:mreale@unich.it

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

Aree

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