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Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
Acquired bases of:
- basic biology
- biochemistry and clinical biochemistry
- molecular biology
Objectives
Contents - Hematopoiesis and functionality of the bone marrow
- hematology: study of anemias
- hematopoietic tumors: leukemias and lymphomas
- glycoprotein tumor markers
- predictive medicine
- mutational analysis in tumors
- personalized therapy
- pharmacogenetics
- immunology and inflammation
- autoimmunity mechanisms
Extended Syllabus - Hematopoiesis and functionality of the bone marrow. Stem cells and study of proliferative progression and cell differentiation mechanisms.
- hematology: study of anemias. Anemias of I, II, III, IV type. Biochemical mechanisms of megaloblastic anemia. Analysis of deficiency anemias and analysis of aplastic anemias. Study of Thalassemias and hemoglobinopathies.
- hematopoietic tumors: leukemias and lymphomas. Classification of lymphomas and leukemias. Study of pathogenetic mechanisms with particular evidence of oncogenic and antioncogenic mutations and of the main transductional alteration partners.
- glycoprotein tumor markers
- predictive medicine. Personalized therapy in tumors and personalization of therapies in cardiovascular diseases.
- mutational analysis in tumors. Somatic mutations and hereditary mutations
- personalized therapy and list of the main drugs used in modern chemotherapy.
- pharmacogenetics on the aspects of pharmacokinetics and pharmacodynamics.
- immunology and inflammation. Acute and chronic inflammations. Study of macrophage function and tissue damage. Analysis of autophagy mechanisms.
- autoimmunity mechanisms. autoimmune syndromes and pathogenesis of celiac disease.
Recommended Bibliography Federici: Medicina di Laboratorio
Teaching Methods Ex catedra lessons
In-depth research papers
development of papers on prepared topics
Evaluation methods Verification of learning:
Oral examination
Discussion of the papers