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Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
Basic knowledge of biology, physiology and chemistry.
Objectives
Contents Learning of the principles of pharmacokinetics (drug absorption, distribution, biotransformation and elimination) and of pharmacodynamics (drug-target interactions). Inter-individual and intra-individual variability of the pharmacological response. Classification of adverse drug reactions. Learning the mechanism of action of the main classes of drugs subject to therapeutic monitoring.
Extended Syllabus Pre-clinical and clinical drug development. Pharmacovigilance. Introduction to general pharmacology: routes of drug administration, principles of pharmacokinetics (absorption, distribution, biotransformation and elimination of the drug); pharmacodynamics (membrane and intracellular receptors; characteristics of drug-receptor interaction; agonists and antagonists; dose-response relationship; therapeutic index). Pharmacogenomics, inter-individual and intra-individual variability factors in drug response.
Adverse drug reactions (hypersensitivity, idiosyncrasy, allergy). Special pharmacology: adrenergic and cholinergic transmission, CNS stimulating drugs, opioids, hallucinogens, cannabinoids, sedative-hypnotic drugs, anti-psychotic drugs, anti-rejection drugs, cardioactive and antiarrhythmic drugs, anti-anemic, anti-aggregating and fibrinolytic drugs.
Recommended Bibliography Pharmacology. MA Clark, R. Finkel, JA Rey, K. Whalen. Ed. Zanichelli.
Pharmacology. HP Sounded, MM Dale, JM Ritter, RJ Flower, G. Henderson. Ed. Elsevier.
Pharmacology: basic principles and therapeutic applications. F. Rossi, V. Cuomo, C. Riccardi, Minerva Medica Editions.
Teaching Methods
Evaluation methods Verification of learning: