Chapter 1.
Structure and organization of the clinical pathology laboratory
Chapter 4
Sources of variability.
Variability of measurement.
Accuracy and Precision.
Sensitivity, LOD, LLOQ, ULOQ, robustness.
Preanalytical errors. Analytical errors.
Hierarchy of analysis methods and reference values.
Chapter 2
Quality in the clinical laboratory
Quality system
ISO 9001 and ISO 15189
Italian accreditation system
Internal and external quality control
Control charts
Chapter 35
Therapeutic drug monitoring
MS and LC-MS analytical methods
Types of MS: single quadrupole, triple quadrupole, ion trap, QTOF
Application of LC-MS to therapeutic drug monitoring: real case