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BIOTECHNOLOGICAL ANALYSIS AND PROTOCOLS OF PREDICTIVE MEDICINE Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
Knowledge of the main application techniques in biomedical laboratories
Fundamentals of biology, chemistry, anatomy, analytical chemistry
Objectives
Contents Fundamentals of analytical chemistry
Sources of variability
Preanalytical and analytical errors
Control charts
Quality system
ISO standards
Accreditation procedure
Therapeutic drug monitoring
Extended Syllabus Chapter 1.
Structure and organization of the clinical pathology laboratory
Chapter 4
Sources of variability.
Variability of measurement.
Accuracy and Precision.
Sensitivity, LOD, LLOQ, ULOQ, robustness.
Preanalytical errors. Analytical errors.
Hierarchy of analysis methods and reference values.
Chapter 2
Quality in the clinical laboratory
Quality system
ISO 9001 and ISO 15189
Italian accreditation system
Internal and external quality control
Control charts
Chapter 35
Therapeutic drug monitoring
MS and LC-MS analytical methods
Types of MS: single quadrupole, triple quadrupole, ion trap, QTOF
Application of LC-MS to therapeutic drug monitoring: real case
Recommended Bibliography Medicina di laboratorio. Logia e Patologia Clinica
Italo Antonozzi, Elio Gulletta
Piccin
2019
Teaching Methods F2F classes with real cases' discussion
Evaluation methods Verification of learning:
Written and/or Oral test on the entire course program. The test will be passed if the candidate reaches the cut-off score of 18/30.
Evaluations will be communicated in due advance and their results will be publicly available.
The following criteria will be used for the candidate assessment:
DATA
CONTENTS: Pertinence and Correctness
DESCRIPTORS:
Complete: 30
Extensive: 29-27
Discrete with some gaps: 26-24
Fully enough: 23-21
Just enough although with several gaps: 20-18
DATA
ARGUMENTS: BREADTH AND COHERENCE
DESCRIPTORS:
Rigorous and documented highlighting ability to use the acquired
knowledge and to link it in the argumentation: 30
Precise and detailed: 29-27
Appropriate: 26-24
Fully enough: 23-21
Just enough: 20-18
--------------------------
DATA
EXPRESSIVE CORRECTNESS, PROPERTY OF SCIENTIFIC
LANGUAGE, COMMUNICATIVE ABILITY
DESCRIPTORS
Refined and original: 30
Clear, flowing and correct: 29-27
Discrete: 26-24
Sufficient: 23-21
Not fully adequate: 20-18