TOXICOLOGY AND APPLIED PHARMACOLOGY

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

Single discipline educational activity

Course Sheet

Course code:

FTA010

Academic Year of enrolment:

2020

Year of supply:

2022/2023

Type of Course:

Elective Course

Degree:

Course of 1st Cycle Degree in SUSTAINABLE TECHNOLOGIES AND ENVIRONMENTAL TOXICOLOGY

Disciplinary Sector:

Pharmacology

Language:

Italian

Location:

CHIETI

Credits:

Programme Year:

Professor and Collaborators:

ORLANDO Giustino

Cycle:

Second semester

Obligatory attendance:

Yes

Minimum hours of attendance:

Hours of classroom activity:

Individual study hours:

Prerequisites:

Pharmacology and Pharmacotherapy.
Students must possess chemical knowledge (general, organic and analytical) and chemical equilibria in order to calculate the effective and toxic concentrations of xenobiotics in medicines and, subsequently, in body fluids and tissues. They must also know: the etiological bases and pathogenetic mechanisms of diseases; the fundamental aspects of the functions of the main organs and systems; the basics of biology and microbiology in the infective or tumor agent host interactions.

Objectives

The objective of the discipline is to deepen and understand the mechanisms that regulate the relationship between toxic substances / drugs and the organism, mechanism of action and organ toxicity of different toxic substances and / or drugs through monitoring of hemoconcentrations and with particular attention to new methods of analysis.The course provides the necessary knowledge for the determination of the toxicological aspects of the active ingredients both in the animal model and in alternative in vitro methods, required for registration purposes and for the assessment of exposure risk.

Contents

Allow the student to deepen and understand the techniques of pharmacological investigation applied in the phase of research and development of drugs (functional studies, binding, biochemical, holistic and reductionist tests) and to develop the ability to use the acquired knowledge. At the end of the course the student will be able to propose the experimental approaches to be adopted in the characterization of drugs or xenobiotics and to correctly interpret, critically, the results of experiments and studies on scientific articles for the preparation of reports and exposures for the future preparation for the discussion of the degree thesis.

Extended Syllabus

Pharmacology applied to the development of new drugs (preclinical and clinical experimental pharmacology) and to the use of drugs as tools for biological research
In vivo procedures: Use of laboratory animals: laws and principles
Tests in vivo for the determination of pharmacological activity ralated to selected drug classes Biological variability; elaboration and statistical analysis of experimental data/results
Applications of Toxicology: Food Toxicology, Analytic/Forensic Toxicology, Clinical Toxicology, Occupational Toxicology, Regulatory Toxicology, Recommended Limits for Occupational Exposure to Chemicals
Data aquisition from scientific literature; structure and analysis of scientific reports; utilization of data banks of the world wide web

Recommended Bibliography

PubMed http://www.ncbi.nlm.nih.gov/pubmed
Caspur Virtual Library http://periodici.caspur.it/
B. G. Katzung, Basic and Clinical Pharmacology published by McGraw-Hill Education.
L. Brunton, B. Knollmann, R. Hilal-Dandan, Goodman and Gilman's The Pharmacological Basis of Therapeutics published by McGraw-Hill Education.

Methods of Provision

Conventional

Teaching Methods

Traditional didactic method through frontal or telematic lessons and classroom exercises and didactic laboratories. Teaching support activities, seminars and ongoing tests are planned. Furthermore, through the use of databases with access to scientific articles, it will be possible to use information not yet available in the most recent treaties to prepare papers that will help prepare students to better deal with the commitment of developing the graduation thesis.

Evaluation methods

Verification of learning:

The exam consists of an oral examination with an exposition of an elaborate typescript on specific issues addressed during the course, taking advantage of an exposure through slides. Further competences will be acquired through the use of scientific databases and articles making use of current information not yet available even in the most recent treaties, helping to prepare students to better face the task of developing the thesis.

Contacts/More Information

The slides projected during the course in PDF format will be available.

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

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