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Single discipline educational activity
Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
As per educational regulation
Objectives
Contents The course describes the role of the placenta in the programming of human development through the introduction of the concept of fetal origin of adult disease (FOAD). The FOAD hypothesis argues that events during early development have a profound impact on the infant's risk of developing future adult disease. Low birth weight, a surrogate marker for poor fetal growth and nutrition, is linked to coronary heart disease, hypertension, obesity, and insulin resistance. The implications of FOAD extend beyond the low birth weight population and include children exposed to stress, both nutritional and non-nutritional, during several critical developmental periods, which ultimately result in a state of disease.
Extended Syllabus Know the characteristics of the human genome:
- study of human genetics
- alterations in the number and structure of chromosomes
- genetic diseases caused by mutations of a single gene
- gene therapy
- counseling and genetic tests
Describe the processes of reproduction:
- asexual and sexual reproduction
- human reproduction: the male
- human reproduction: the female
- the sexual response
- fertilization and the early stages of development
- childbirth
Describe the processes of animal development:
- the development of the form
- fertilization
- segmentation
- gastrulation
- organogenesis
- the extraembryonic membranes
- human development
Explain the concepts of developmental genetics:
- cellular differentiation and nuclear equivalence
- genetic control of development
- epigenomics and epigenetics
- Definition and historical notes
- Epigenetic modifications: histones and methylation
- Epigenetics: introduction and historical notes
- Epigenetics, environment and lifestyles
- Epigenetics and diseases
- Epigenetics and nutrition
The origins of health and disease:
- Barker's hypothesis
-The plasticity of the fetus and the response to possible intrauterine adverse events
-The Adaptive Predictive Model (PAR)
-The role of the placenta
-The role of genetics
Recommended Bibliography Didactic material provided by the teacher
Teaching Methods
Evaluation methods Verification of learning:
The student's evaluation includes a written test (Multiple choice test), which will serve to demonstrate knowledge of the program carried out and the logic followed by the student in solving the questions posed. At the end, an eligibility will be attributed.
Contacts/More Information Prof.ssa Sara Franceschelli: Università degli studi G. D'Annunzio, Palazzina Farmacia corpo D livello 1
Tel. 0871-3554539 email: sara.franceschelli@unich.it