"G. d'Annunzio"
Basics of genetics and molecular biology
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The objective of this course is to give the student the necessary basis forunderstand the role of genetics in hereditary diseases and molecular biology techniques used in the study of the genome and transcriptome and pharmacogenetics.
The course on Molecular Genetics will deal with topics focused on the study of the genetic basis of the normal and pathological human characters. Topics such as the genetics of congenital diseases, genetics of cancer, genetics of common diseases, reproduction, prenatal diagnosis, neonatal screening will be analyzed. Particular interest will be devoted to molecular biology techniques used in the study of the genome and transcriptome and pharmacogenetics.
The gene and its modifications - Methods of cell culture - The human karyotype and its modifications - Molecular biology techniques: DNA amplification (PCR) DNA analysis with MLPA, Sequencing - Studies of gene expression - RT-PCR, microarray - The Human Genome - Techniques of Molecular Cytogenetics: FISH SKY array-CGH - Stem Cells - Stem cells and cancer - Animal models and genetic diseases - Genetic Testing: Diagnostic Tests Pre-clinical tests Predictive Test
Handouts
Frontal lessons with slide support. Practical exercises in laboratory.
The exam will consist of an oral interview with the teacher aimed at assessing the knowledge and understanding of the topics covered during the course. The vote is expressed as suitable / not suitable.
the frequency is mandatory with a minimum of 70% hours
