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Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
BASIC BIOLOGICAL SCIENCES (TOC11A2) (required)
BASIC PROPEDEUTIC SCIENCES (TOC11A1) (recommended)
Objectives
Contents The laws of inheritance, structure and functions of DNA and chromosomes, mutations and genetic diseases, major chromosomal syndromes.
Extended Syllabus - Gene structure and function. Protein synthesis, genetic code, regulation of gene expression.
- Cell division. Mitosis, meiosis,
- Cytogenetics. Notes on cytogenetic techniques, normal human karyotype, chromosomal banding.
- Chromosomal abnormalities. Numerical and structural alterations of chromosomes. Main chromosomal syndromes.
- Prenatal diagnosis.
- Mendel's laws. Autosomal dominant and recessive inheritance, heterosomal inheritance, mitochondrial inheritance. Polygenic inheritance. Particularity of the Mendel laws.
- Mutations. Point mutations, frameshift, dynamics. Chemical and physical mutagens.
Chromosomal alterations and spontaneous abortions.
- Principal techniques of molecular biology and their applications. Gene cloning.
- Oncogenes and oncosuppressor genes.
Recommended Bibliography G. Palka: Genetica Umana
M Clementi: Elementi di Genetica Medica.
Teaching Methods
Evaluation methods Verification of learning:
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