Error message
User error : Failed to connect to memcache server: druportbe01:11211 in dmemcache_object() (line 415 of /production/drupal/dim_prod/drupal/d7cl4/prod/unich/releases/7/web/sites/all/modules/contrib/memcache/dmemcache.inc ).
Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
Knowledge of physiology, biochemistry and general pathology
Objectives
Contents The course of Clinical Pathology intends to clarify the different elements that contribute to
study the physiology and pathophysiology of organs and tissues with reference to
biocellular and biochemical parameters that measure the main pathological conditions. There
discipline is also interested in the application of disease prediction markers in
oncological, cardiovascular and neurological fields.
Extended Syllabus The program is divided into the following points:
a) acquisition of the basic elements related to the pathophysiology of blood and blood
components. Clinical evaluation of anemias and study of related parameters. Analysis
clinics of leukemias and lymphomas and staging.
b) Pathophysiology of haemostasis. Analysis of the components of the coagulation cascade.
Clinical evaluations of coagulative-deficient states. Deficiency of the factors and their
role in hemorrhagic states.
c) Parameters of immunological investigation. Diagnostic-clinical evaluation
inflammation and the role of cellular components. Immunophenotyping and his
application in the principals of immunodeficiency and neoplastic induction.
Study of autoimmunity and description of the main autoimmune syndromes: disease
celiac disease, reactive pathologies of the gastro-enteric system (M. of Chron, rectocolitis
ulcerative), Sijogren's syndrome, SLE, rheumatoid arthritis, scleroderma
d) Tumor serological markers. Analysis of the molecular alterations of the main ones
genes in the pathogenic processes of tumors. Pathogenesis of gastro-enteric tumors.
Predictive Medicine principles and study of prediction markers for the main ones
family oncological syndromes: breast and ovary cancer, HNPCC, tumors
Hereditary thyroid, retinoblastoma, Li-Fraumeni syndrome
e) Principles of pharmacogenetics and pharmacogenomics. Prediction of the answer
therapeutic in tumors. Presentation of the main application protocols
molecular-diagnostic in the chemotherapeutic orientation of neoplasms.
Recommended Bibliography G. Federici et al. Medicina di Laboratorio. McGraw Hill
Teaching Methods
Evaluation methods Verification of learning:
- oral interview
- presentation of papers on specific pre-assigned topics
Contacts/More Information presentation of clinical cases