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Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
As stated by academic rules
Objectives
Contents The course includes two sections:
1) General pharmacology. This section describes the principles that underlie the human-drug interactions and that in turn are divided into two chapters, the one related to Pharmacokinetics (the effects that the body has on drugs) and the one on Pharmacodynamics (the cellular and molecular mechanisms that underlie the therapeutic, unwanted and toxic effects of drugs).
2) Special Pharmacology. This section describes the characteristics of the single classes of drugs (in particular those of the most common use in nuclear medicine).
Extended Syllabus • Introduction to Pharmacokinetics: absorption, distribution, metabolism, elimination.
• Introduction to Pharmacodynamics: receptor, receptor signal transduction mechanisms, agonist and antagonist concept, potency and efficacy of a drug, therapeutic index
• Principles of radiopharmaceutical therapy
•Classification of immune-mediated reactions to drugs and contrast media.
•Reactions to contrast media[examples of premedication and therapy (Pharmacology of histaminergic transmission and cortisonic drugs)]
Recommended Bibliography Rang HP, Dale MM, Ritter JM “FARMACOLOGIA”, Casa Editrice Ambrosiana
F. Clementi e G. Fumagalli. Farmacologia generale e molecolare. Editore:UTET
Teaching Methods The course includes lectures and interactive lessons.
The course aims to provide the theoretical basis necessary for a reasoned understanding of what the drug produces once it has been introduced into the human organism (pharmacodynamics) taking into account how it is distributed and modified in the organism itself (pharmacokinetics). At the same time, special care will be taken in linking theoretical knowledge with the evidence emerging from the use of drugs as tools of therapeutic armamentarium. In itinere will be proposed exercises (multiple choice tests) to verify the level of personal learning on the various topics covered
Evaluation methods Verification of learning:
The learning will be evaluated through a final oral assessment.
The examination procedure and its evaluation are indicated by the teacher at the beginning of the lessons.
Contacts/More Information Prof. Patrignani receives the students on Wednesday from h 3pm to h 6pm, after taking appointment to via email: ppatrignani@unich .