Introduction: History of Medicine and History of Pathology - Pathological
systematics and paleopathology (the problem of nosography in human
pathology, definition of pathological taxa) - Instability of diseases -
Determinants of human diseases (ecological concept of disease).
Determinative components of human diseases (ecological concept of
disease).
Host, agent and environmental variability concept - Host-related
instability, agent-related instability, environmental instability -
Epidemiological equilibrium concept - Natural selection and human
pathology. Pathocenosis - Laws of human patocenosis (Grmek's laws).
Fundamental concepts of the biological evolution of humans with
particular regard to the inter-relationships between biological
evolutionary stage and characteristically associated diseases - Population
structure and pathocenosis - Overview of human populations’
demographic history (three productive economic phases in historical
succession) with examples of demographic history - Disorders related to
changes in demographic parameters (infant mortality, population density,
birth rate, average life span), with particular attention paid to oral
diseases. Production capacity, food resources, typology of socio-economic
models and human pathocenosis - Concept of real biomass and critical
biomass - The role of infectious diseases in the human ecosystem.
History of infectious diseases - Infectious diseases as a fundamental
component of the evolving human ecosystem - The dynamic parasite /
host - Concept of infectious disease The biological role of infectious
diseases as a fundamental component of the evolving human ecosystem
- Role of infectious diseases in natural selection - Epidemiological
Transition Concept.
Origin and phylogenetic classification of current human pathogens -
Elements of the evolution of the immune system.
Phylogenetic classification of current human diseases - Diseases due to
endogenous causes (historical examples, with particular reference to the
"side effects of biological evolution").
Diseases from exogenous cause (historical examples).