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MOLECULAR TECHNOLOGIES IN ORAL CANCER PATHOLOGY Course Sheet Academic Year of enrolment:
Disciplinary Sector:
Laboratory Medicine Techniques
Professor and Collaborators:
Hours of classroom activity:
Objectives Contents This module of the laboratory medicine course aims at providing the student with a knowledge of the molecular mechanisms underlying development and progression of pathology in the oral cavity, with particular attention at the carcinogenesis of this anatomic site.
Extended Syllabus Carcinogenesis: general key concepts. Molecular alterations of the key genes involved in the pathogenetic processes of cancerogenesis.
Molecular mechanisms of the pathobiology of Head and Neck and of Oral Cancers
Biomarkers Derived from Key Processes
Role of HPV in the development of the Oral Squamous Cell Carcinoma
Role of EBV in the development of the Squamous Cell Carcinoma of the Nasopharynx
Epigenetic Changes and Epigenetic Targets in Head and Neck Cancers
Mechanisms involved in the invasion and metastasis of the Head and Neck Cancers: molecular signaling, tumor-stroma interactions, cancer stem cells
Animal models of the oral carcinogenesis
Recommended Bibliography Lesson notes, international literature (Medline)
Teaching Methods Traditional lessons, integrated with “journal club” sessions for discussion of the most important scientific papers in this field.
Evaluation methods Verification of learning:
Oral examination
Contacts/More Information Student-Teacher Conference: to set-up by sending an e-mail to the following address: marco.trerotola@unich.it
