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APPLIED MEDICAL SCIENCES AND TECHNIQUES III Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Objectives
Contents The course includes a description of the various components of the heart-lung machine, retracing the history of the development of the current components. Furthermore, the main monitoring and protocols (priming, hemodilution, hypothermia, cardioplegia) used during the cardio-pulmonary bypass (CBP) will be described. To this end, and to facilitate the student, some concepts relating to the anatomy and physiology of the cardiovascular system will be recalled with particular attention to the main mechanisms underlying vascular alterations: endothelial function / dysfunction and role of nitric oxide (NO).
Extended Syllabus 1. References to the main themes of anatomy and physiology of the cardiovascular system (HEART)
2. References to the main themes of anatomy and physiology of the cardiovascular system (BLOOD VESSELS)
3. Endothelium and its functions in vascular homeostasis: role of Nitric Oxide (NO)
Endothelial dysfunction and atherosclerosis: role of oxidative stress and inflammation
4. Mechanisms underlying the development of vascular complications in various diseases, such as: hypertension, insulin resistance, diabetes, obesity and uremia. Evaluation of endothelial function: classical methods and development of new biomarkers
5. Cardiopulmonary Bypass (CPB): history
6. CPB: materials and devices
7. CPB: preparation of patients
8. CPB: Priming and Cardioplegia
9. Monitoring during CPB
10. CPB: hypothermia
11. CPB: acid-base balance
12. Outline on CPB weaning and arrest.
As part of the discussion of the various topics, gender differences will be addressed.
Recommended Bibliography The student will be provided with slides relating to the lessons, accompanied by articles and reviews of the literature relating to the topics covered.
However, during the three-year course of the MED / 50 discipline, students could consider the following texts:
- Glenn P. Gravlee, Richard F Davis, Alfred H. Stammeres, Ross M. Ungerleide
Cardiopulmonary Bypass - Principle and Practice
3rd edition
Ed Lippincott Williams and Wilkins
- Glenn P. Gravlee, Richard F. Davis John Hammon, Barry Kussman
Cardiopulmonary Bypass and Mechanical Support - Principle and Practice
4th edition
Ed Lippincott Williams and Wilkins
- Albert C. Perrino, Florian Falter, Sunit Ghosh
Cardiopulmonary Bypass
2nd edition
Ed: Cambridge University Press
Teaching Methods The course will consist of lectures.
Evaluation methods Verification of learning:
The final exam consists of an oral test.
Contacts/More Information During the lesson, the teacher will provide the contact details to be contacted.