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Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
According to learning regulations
Objectives
Contents Elements of Organic Chemistry. Stucture and function of Biomolecules. Enzymes. Bioenergetics and Metabolism of Biomolecules.
Extended Syllabus PART I: Introduction to Biochemistry
Elements of Organic Chemistry:
General Overview of Carbon Compounds. Alkanes, Alkenes, Alkynes, Benzene. Overview of Functional Groups: Alcohols, Ethers and Phenols. Aldehydes and Ketones. Amines and Heterocycles.
Energy Changes in Chemical Reactions and Chemical Thermodynamics:
Thermodynamics and Work. The First and The Second Law of Thermodynamics. Enthalpy and Entropy Free Energy. Spontaneity and Equilibrium. Thermodynamics and Life.
Enzymes: classification, kinetics, and control
PART II: STRUCTURE AND FUNCTION OF BIOMOLECULES
Carbohydrate: General aspects and classification. Monosaccharides, Disaccharides and Polysaccharides.
Lipids: General aspects and classification. Fatty Acids, Triglycerides, Phospholipids, Sterols and Cholesterol.
Proteins: Amino Acids, Peptides, and Proteins. Covalent structures and three-dimensional structures of proteins. Protein Folding and Dynamics. Hemoglobin and Mioblobin. Protein Function
Pathological Hemoglobin.
Nucleic Acids: structure, fuction and general aspects. Nucleotides and Nucleosides
PART III: METABOLISM
Introduction to Metabolism:
Carbohydrate metabolism I: major metabolic pathways and their control. Glycolysis. Citric Acid Cycle. Electron Transport and Oxidative Phosphorylation. Carbohydrate metabolism II: special pathways and glycoconjugates. Glycogen Metabolism, Gluconeogenesis and the Pentose Phosphate Pathway.
Lipid Metabolism: utilization and storage of energy in lipid form. Pathways of metabolism of special lipids: β-oxidation and ketogenesis.
Protein Metabolism: Amino acid metabolism and Urea cycle.
Recommended Bibliography Chimica e Biochimica" (lauree brevi), M.Samaja-R.Paroni. PICCIN Editore
Teaching Methods
Evaluation methods Verification of learning:
Oral exam
The exam method is an oral and written test designed to verify the results of the expected learning, in accordance with the educational and specific objectives of the course. The oral examination is placed at the end of the course, after having achieved the attendance to the same, according to a schedule established and published on the University web page at the beginning of the academic year. The outcome of the test is evaluated as the result of learning the specific and training objectives, such as knowledge and understanding, capacity for logical integration and application. At the end of the test the teacher will form an opinion expressed in terms of Italian grades and their correspondent European Credit Transfer System grade (In Italian Universities grades are given on the basis of 30 points).
1) Rating 30 - 30 cum laude (corresponding to ECTS grade A): Excellent knowledge and understanding of the subjects, ability to reason and logical integration of the acquired knowledge. If the student, who has achieved this evaluation, demonstrates autonomy of judgment, high communication skills and autonomous learning skills, a laude can be added by the commision.
2) Rating 27 - 29 (corresponding to ECTS grade B): Good knowledge and understanding of the topics with some non-serious inaccuracies and with a good capacity for logical integration and judgment.
3) Rating: 23 - 26 (corresponding to ECTS grade C): Discrete knowledge and understanding of the topics and, despite some gaps in the ability to integrate and apply knowledge.
4) Rating 20 - 22 (corresponding to ECTS grade D): Knowledge and understanding of the arguments fully sufficient, although there are clear gaps, which are reflected in a reduced capacity for integration, logic and application.
5) Rating 18 - 19 (corresponding to ECTS grade E): Knowledge and understanding of the topics with serious and evident gaps, with limited integrative and applicative skills, but which also allow the passing of the exam.
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