Organic Analysis. Qualitative analysis of organic compounds. Preliminary evaluation: organoleptic analysis, structure chemical-physical properties relationships. Drugs solubility. Structure-Solubility relationships. Melting point. Eutetics. Polimorfism and techniques for the characterization of the polymorphs. Boiling point. Rifractometry. Polarimetry. Optical Rotatory Dispersion. Circular Dicroism. Qualitative elemental analysis. Functional organic analysis.
Separation and Purification Methods. Cristallization. Filtration. Liquids purificatio: Ideal and real misture. Azeotropics. Distillation. Sublimation. Liquid- Liquid Extraction. Continuous extraction. Soxhlet apparatus. Theoretical basis of chromatography. Planar and on column chromatography. HPLC. Gas-chromatography. Supercritical Fluids chromatography. Chromatographic resolution of racemic misture. Method validation. Chromatographic quantitative analysis. Hyphenated techniques.
Capillary Electrophoresis. Theoretical basis. Instrument. Analytical parameters: efficency, mobility, resolution. EOF. Joule effect. CZE. Chiral selectors.
Determination of drugs physico-chemical parameters. Evaluation of acid dissociation constant (pKa), lipophilicity (logP) solubility, chemical stability.
Pharmacopoeia. FU drugs identification procedures.
.

Laboratory exercitations.
Solubility evaluation of organic and organometallic compounds. Identification of the unsaturated compounds, carbonyls, alcohols, phenols, carbohydrates, amines, aminoacids, and carboxylic acids. M.p. evaluation. FU compounds identification.Liquid-Liquid Extraction of a given mixture. TLC. Cristallization. Column chromatography