TOXICOLOGY

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

Single discipline educational activity

Course Sheet

Course code:

02656

Academic Year of enrolment:

2018

Year of supply:

2021/2022

Type of Course:

Characterising

Degree:

Course of Single Cycle Degree 5 years in MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY

Disciplinary Sector:

Pharmacology

Language:

Italian

Location:

CHIETI

Credits:

Programme Year:

Professor and Collaborators:

LEONE Sheila

Cycle:

First semester

Obligatory attendance:

Yes

Minimum hours of attendance:

Hours of classroom activity:

Individual study hours:

136

Prerequisites:

It is advisable to have already acquired the basic notions of Pharmacology.

Objectives

The aim of the discipline is to understand the general mechanisms that regulate the relationship between toxic substances / drugs / organism and the mechanism of action and organ toxicity of different toxic substances and / or drugs.
The course aims to teach students the knowledge of chemical, chemical and physical analysis and of substances in order to evaluate the toxicological risk on public health.
Through lectures, consultation of the reference text and scientific literature, students will be able to learn topics in a critical way regarding issues related to toxicology.

Contents

Toxic substance, mechanism of toxicity, toxic effect. Adverse reactions, tolerance levels

Extended Syllabus

General princicples of Toxicology - History and scope of toxicology -
Kinetic and dynamic of toxic drugs - Mechanisms of toxicity -
Absorption, Distribution, and Excretion of Toxicants
Biotransformation of xenobiotics –
Approach to the patient - Decontamination - Purification - Antidotes.
Toxicology of metals and metalloids, organic solvents and vapors, atmospheric pollutants, pesticides. and other agricultural products (insecticides, fungicides, herbicides, bactericides), fungi and animal toxins (viper, bees, wasps, hornets, spiders and fish), herbs and poisonous plants. Food toxicology.
Drugs addiction
Sedative-hypnotics, opiate analgesics, psycho stimulants, hallucinogens-psychedelics. Doping drugs.

Recommended Bibliography

Casarett & Doull’s - Tossicologia, EMSI
B.G. Katzung, Farmacologia Generale e Clinica, IX° Edizione italiana sulla XII° di lingua inglese, edito da Piccin
Goodman & Gilman, Le Basi Farmacologiche della Terapia, XII edizione, edito da Zanicchelli

Methods of Provision

Conventional

Teaching Methods

The teaching is structured in 64 hours front, divided into 2 hours lessons. The frontal teaching consists of theoretical lessons in the classroom and exercises in educational workshops. During the teaching, individual and / or group works will be proposed to the students. Moreover the proposed exercises will allow to verify the practical application of the topics addressed during the theoretical course.

A minimum frequency of 54 hours is required

Evaluation methods

Verification of learning:

The exam consists of an oral test. The topics under examination will reflect those dealt with during the course and present in the program. The personal contribution of the student, of his activity, of the commitment and constancy shown during the period of attendance will be evaluated
To pass the exam it will be necessary to acquire a correct, clear and concise terminology, paying attention to the possible logical links between the topics developed during the course of study.

Contacts/More Information

The slides projected during the course in pdf format will be available on the Department's website in the teacher's section

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

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