The recent pandemic emergency has contributed (with chronological limits not yet definitively defined) to rendering "global" those problems and questions that have remained so far untraced among knowledge as well as between political, economic and social frameworks. Those, which up to now appeared to be related to some narrow area of epistemological competence, have revealed to be humanly, culturally and universally transversal not only to areas and individuals, but also to competences and systems, and to activities and living spaces. It is mankind – both individually and socially, anywhere and elsewhere - who find these competences on themselves and have to deal with them, as they are inevitable. Sense of life and death, reason for belonging, need for a hardly consumable link, authenticity and reality of a relationship ... up to the radical questioning of the very possibility of human life in the pathogenic context of the present world. Such a patchwork of questions assumes unsettling radicalities and peculiarities even for a more prudent rationality. Being able to make them the object of common thought and reflection, by making use of contributions and significant texts, seems to be a way to exercise and "risk" a lively philosophical rationality, across the border: up to invest and take on the urgencies of the modern economic and social life. Dialogue is open to contributions from any experience, in order to render it a full thought as to its vital "vulnerability". Always open to any discovery ...