AFM - Atomic Force Microscopy Of Pharmaceutical Samples
• Theoretical operating principles:
-Introduction to the atomic force microscopy technique and related instrumentation for the study of the surfaces of compounds of various kinds at the nanometric scale.
• Analysis modes:
-Surface topographic analysis using Contact Mode, Tapping Mode and Peak Force Tapping (ScanAsyst in Air Mode)
-Analysis of nanomechanical properties of materials by PeakForce Quantitative Nanomechanical Property mapping (PFQNM)
-Analysis in fluid
• Instrument setup and sample preparation:
- Probe selection and installation,
- Laser alignment,
- Instrument calibration
- Optimization of scan parameters to minimize sample and probe degradation
• Analysis of materials for pharmaceutical use
- Materials for biomedical use
- Small microorganisms or microvesicles
- Drug delivery systems
DSC/TGA - Laboratory Of Thermal Analysis
• Introduction thermal analysis
Presentation of thermal analysis and its role in the characterization of materials. In-depth description of the fundamental principles, including the measurement of heat changes during thermal transitions.
• Sample Preparation and Experimental Procedures
Illustration of the sample preparation requirements for analysis, including the selection of suitable materials and containers. Detailed guidance on key experimental parameters used, such as heating rate and temperature range. Step-by-step guide to configuring and conducting an experiment.
• Data Analysis
Discussion of notable features in data, such as endothermic and exothermic peaks, phase transitions, and chemical reactions. Explanation of data analysis techniques employed, such as determining specific heat and enthalpies of fusion. Practical examples of data interpretation for different applications and types of materials with particular reference to samples for pharmaceutical use.
• Results Interpretation and Considerations
In-depth exploration of accurate interpretation of results, considering baseline effects, interferences, and method limitations. Discussion of potential sources of error and strategies to minimize them during analysis. Exploration of correlations between results and thermal or thermodynamic properties of materials.
