INNOVATIVE PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL EVALUATION OF DRUGS

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

Single discipline educational activity

Course Sheet

Course code:

FFI010

Academic Year of enrolment:

2017

Year of supply:

2021/2022

Degree:

Course of Single Cycle Degree 5 years in PHARMACY

Language:

Italian

Moduls:

Drug Delivery - 1 credits
biological tests of drugs - 1 credits

Location:

CHIETI

Credits:

Programme Year:

Cycle:

First semester

Obligatory attendance:

Yes

Hours of classroom activity:

Prerequisites:

Pharmaceutical Technology
Human Anatomy

Objectives

Synthesis, physicochemical characterization and analysis of drug delivery systems in nanotechnology and nanomedicine. Students will learn fundamentals for the synthesis, physicochemical characterization and biological tests of drug delivery systems and medical devices.

The course aims at proposing a comprehensive view of basal procedures and assays used for the biological evaluation of newly synthetized compounds, nanomaterials and drug delivery

Contents

FUNDAMENTALS OF DRUG DELIVERY SYSTEMS:
Introduction to drug delivery systems and nanomedicine.

DRUG DELIVERY SYSTEMS:
Fundamentals: Differences between drug delivery systems and conventional drug dosage form. Mechanisms of diffusion and transport of drugs modulated by drug delivery systems. Biopharmaceutical and technological properties of drug delivery systems. Biomaterials in drug delivery. Passive and active targeting. Lipid and polymeric drug delivery systems. Nanometric implantable devices.

Examples of drug delivery systems: Lipid drug delivery systems (Doxil/Caelyx). Polymeric drug delivery systems (Abraxane). Nanochannel biomedical devices (nDS).

Cell organization and communication.
In vitro cell culture models: primary cell cultures, normal and cancer cell lines.
In vitro metabolic activity and cytotoxicity assays.
Study of the intracellular trafficking in response to different pharmaceutical systems by means of flow cytometry, fluorescence microscopy, transmission and scanning electron microscopy, atomic force microscopy.

Extended Syllabus

FUNDAMENTALS OF DRUG DELIVERY SYSTEMS:
Introduction to drug delivery systems and nanomedicine.

Examples of drug delivery systems: Lipid drug delivery systems (Doxil/Caelyx). Polymeric drug delivery systems (Abraxane). Nanochannel biomedical devices (nDS).

Recommended Bibliography

COLOMBO P., CATELLANI P.L., GAZZANIGA A., MENEGATTI E., VIDALE E., Principi di tecnologie farmaceutiche, Ambrosiana, Milano, Ultima edizione. AULTON Tecnologie Farmaceutiche, Progettazione e allestimento dei medicinali, Caviglioli G., Coviello T., De Rosa G., Modena T., Ultima edizione. A.T. FLORENCE, D. ATTWOOD Le basi chimico-fisiche della tecnologia farmaceutica. Edises Ultima edizione.

Methods of Provision

Conventional

Teaching Methods

Classes: 2 h
Individual Training: 2 h
12 hours of lectures

Evaluation methods

Verification of learning:

Oral discussion of topics included in the program.
4 different questions, 2 questions for each modules discussing the thematic issues of the program
Minimum score for the approval: 18/30.
Oral examination

Contacts/More Information

Classes: 2 h
Individual Training: 2 h
12 hours of lectures

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

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