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BIOINFORMATICS PRINCIPLES AND BIG DATA ANALYSIS APPLIED TO ENVIRONMENTAL TOXICOLOGY Single discipline educational activity
Course Sheet Academic Year of enrolment:
Professor and Collaborators:
Hours of classroom activity:
Prerequisites:
The main prerequisites are the knowledge of the basics of mathematics and physics for the understanding of mathematical functions and for the relative graphic interpretation of the same; Knowledge of the basics of general and organic chemistry.
Pre-requisites: Mathematics, Physics, General Chemistry, Organic chemistry.
Objectives
Contents • Principles of statistics and bioinformatics.
• Computational methods and big data.
• Environmental Contaminants: Sources of Exposure, Biological Mechanisms, and Impacts on Health.
• Big data analytics for human health.
Extended Syllabus Principles of statistics: normal and binomial distribution, random variables, and distribution functions. Multivariate analysis. Data visualization. PCA, cluster analysis and classification methods.
Introduction to bioinformatics: DNA, RNA and protein sequences. Computational biology and sequence alignment. Genetics Epigenomics Transcriptomics Proteomics Metabolomics. Big data: definitions and classification.
Main environmental contaminants: Arsenic, Lead, Mercury, Vinyl Chloride, Polychlorinated Biphenyls, Benzene, Cadmium, Polycyclic Aromatic. Carcinogenic, Organic Hazardous Air Pollutants. Environmental Contaminants of Emerging Concern.
Recommended Bibliography • REBECCA C. FRY: “Systems Biology in TOXICOLOGY AND ENVIRONMENTAL HEALTH” Elsevier Academic Press.
• Maria Cristina Mariani, Osei Kofi Tweneboah, Maria Pia Beccar-Varela: “Data Science in Theory and Practice” John Wiley and Sons, Inc.
• teaching materials provided by the lecturer.
Methods of Provision
Teaching Methods
Evaluation methods Verification of learning:
Oral exam: questions related to several topics explained during the lectures in which the interpretation and the discussion of concepts and data is required.
Contacts/More Information 3 CFU – 24 hours. Office hours to be prebooked (by e-mail or phone).