The psychosomatic model and the interaction between mental and somatic functions. The biopsychosocial model and the interactions between macro- and micro-systems. The models of Damasio, Panksepp, and Solms. The alexithymia construct. Somatic determinants of psychological health: gene-environment interactions, the immune system, proinflammatory mechanisms. Psychological determinants of somatic health: interpersonal relationships, somatosensory amplification, illness representations, abnormal illness behavior. Psycho-neuro-endocrino-immunology. The role of adaptation and psychological aspects of stress. Interpretive models of stress and health: psycho-infectivology, cognitive and psychopathological aspects of HIV and HCV infection, pediatric psycho-infectivology (Lyme disease, PANDAS).